![]() ![]() ![]() Recent advances in biotechnology such as metabonomics and toxicogenomics have been providing novel tools to elucidate the mechanisms of PLDsis and to establish biomarkers for screening tests in the preclinical stages and for monitoring in the clinical phases in addition to conventional approaches such as morphology (lamellar bodies) and biochemical methods including assays of specific metabolites and phospholipase inhibition. Thus, the assessment of potential target organ dysfunction and the identification of clinical biomarkers are important objectives for new drug development. Although these alterations are generally reversible after cessation of drug treatment, PLDsis is of regulatory concern and an issue for drug safety for pharmaceutical companies. The inducing drug also accumulates in association with the excess phospholipid. Physician Program Director, Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma Therapeutics Kraft Family Professor of Medicine, Harvard. Price per Unit: 0.10671 per EA NDC Code 60951-602-85 Package Description: 500 TABLET in 1 BOTTLE Price per Unit: 0.10671 per EA Product Details What is NDC 60951-602 The NDC code 60951-602 is assigned by the FDA to the product Endocet which is a human prescription drug product labeled by Par Pharmaceutical, Inc. Massive accumulations can occur in animal tissues such as the lung with little effect on organ function. In affected cells the appearance of membrane-bound inclusions, primarily lysosomal in origin, with a lamellar structure (lamellar bodies) is a definitive morphologic hallmark. Numerous drugs and chemicals are capable of inducing the storage disorder in animals and humans however, despite their diverse pharmacological activities, each of these drugs shares common physicochemical properties: a hydrophobic aromatic ring structure on the molecule and a hydrophilic side chain with a charged cationic amine group and therefore are in the group of cationic amphiphilic drugs. ![]() Drug-induced phospholipidosis (PLDsis) is an excessive accumulation of polar phospholipids in cells or tissues/organs caused by xenobiotics. ![]()
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